Cytotoxic Acridone Alkaloids from the Stem Bark of<i>Citrus Maxima</i>

Abstract

A new acridone alkaloid, 5-hydroxynoracronycine alcohol (4), along with six known acridone alkaloids, glycocitrine-I (1), 5-hydroxynoracronycine (2), citrusinine-I (3), grandisine-I (5), natsucitrine-II (6), and citracridone-III (7), were isolated from the stem bark of Citrus maxima f. buntan. Their structures were established on the basis of spectroscopic methods. Compounds 1-4 and 7 were found to be cytotoxic on two tumor cell lines.