A shape memory hydrogel induced by the interactions between metal ions and phosphate

Abstract

A novel ferric-phosphate induced shape memory (SM) hydrogel is prepared by the one-step copolymerization of isopropenyl phosphonic acid (IPPA) and acrylamide (AM) in the presence of a crosslinker polyethylene glycol diacrylate (PEGDA). Different from the traditional SM hydrogels, our SM hydrogel can be processed into various shapes as needed and recovers to its original form in ‘multiconditions’ such as in the presence of a reducing agent or in the presence of a competitive complexing agent. This unique feature is attributed to the fact that the oxidized ferric ions show a high complexation ability with phosphate groups of IPPA, which acts as a physical crosslinker to form the secondary networks within the hydrogels to induce the shape memory effect. The memory behavior was totally reversible, owing to Fe3+ that can be reduced to Fe2+ and extracted by the complexing agent. Particularly, the SM hydrogels exhibit controllable and good mechanical characteristics by introduction of the ferric ions, i.e., the elastic modulus can increase from 2 kPa to 70 kPa dramatically. Learning from biological systems, phosphate-metal ion based hydrogels could become an attractive candidate for various biomedical and environmental applications.