<b>Augmented Noradrenaline Release Following Nerve Stimulation after Inhibition of Prostaglandin Synthesis with Indomethacin</b>

Abstract

Abstract The effect of inhibition of prostaglandin synthesis on the release of noradrenaline induced by sympathetic nerve stimulation was studied in the isolated perfused rabbit heart. It was found that indomethacin (Indomeé®, Merck, Sharp and Dohme), a drug known to inhibit prostaglandin synthesis, decreased the outflow of prostaglandins normally induced by nerve stimulation. Simultaneously the outflow of noradrenaline in response to nerve stimulation was augmented. Since indomethacin neither caused any release of noradrenaline heart in the absence of nerve stimulation, nor affected the uptake of exogenous noradrenaline, it is concluded, that the increased noradrenaline release reflects disinhibition of a feed‐back mechanism, using endogenously formed prostaglandins for limitation of noradrenaline release.