Efficient Construction of Oxa‐ and Aza‐[<i>n</i>.2.1] Skeletons: Lewis Acid Catalyzed Intramolecular [3+2] Cycloaddition of Cyclopropane 1,1‐Diesters with Carbonyls and Imines

Abstract

Building bridges: A Lewis acid promoted intramolecular [3+2] cycloaddition of cyclopropane 1,1-diesters with aldehydes, ketones, and imines (see scheme) has been developed to provide a general and efficient strategy for construction of bridged oxa- and aza-[n.2.1] (n=2,3,4) skeletons. To highlight this method, the core of platensimycin was also constructed. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.