Concepedia

Downregulation of miR‐21 is Involved in Direct Actions of Ursolic Acid on the Heart: Implications for Cardiac Fibrosis and Hypertrophy

Xingli Dong, Shangkun Liu, Lingling Zhang, Siming Yu, Linman Huo, Muge Qile, Lu Liu, Baofeng Yang, Jin‐Ling Yu

Cardiovascular Therapeutics · 2015 · 32 citations · 24 references

DOI

Abstract

Our study demonstrates that UA can inhibit myocardial fibrosis both in vitro and in vivo, and the effects of UA on myocardial fibrosis may be due to the inhibition of miR-21/ERK signaling pathways.

References

24

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

Thomas Thum, Carina Gross, Jan Fiedler et al. · Nature · 2008 · 2.3K citations

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Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis

Eva van Rooij, Lillian B. Sutherland, Jeffrey E. Thatcher et al. · Proceedings of the National Academy of Sciences · 2008 · 1.8K citations · Full text

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A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure

Eva van Rooij, Lillian B. Sutherland, Ning Liu et al. · Proceedings of the National Academy of Sciences · 2006 · 1.5K citations · Full text

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Cardiac fibroblast–derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy

Claudia Bang, Sándor Bátkai, Seema Dangwal et al. · Journal of Clinical Investigation · 2014 · 969 citations · Full text

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Myocardial scarring in asymptomatic or mildly symptomatic patients with hypertrophic cardiomyopathy

Lubna Choudhury, Heiko Mahrholdt, Anja Wagner et al. · Journal of the American College of Cardiology · 2002 · 627 citations

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