Induction of Atherosclerotic Plaque Rupture in Apolipoprotein E ^−/− Mice After Adenovirus-Mediated Transfer of p53

Abstract

We have demonstrated a potential role of p53-induced remodeling in atherosclerotic plaque destabilization. Being the first example of inducible rupture at a predefined location, this model offers a unique opportunity to delineate the processes that precede rupture and to evaluate plaque-stabilizing therapies.