Direct Synthesis of a Thiolato‐S and Sulfinato‐S Co^III Complex Related to the Active Site of Nitrile Hydratase: A Pathway to the Post‐Translational Oxidation of the Protein

Abstract

Cyclic pseudopeptidic thiosulfinates reveal a new type of reaction that may be important in biological systems. It involves hydrolytic cleavage of the S(O)S bond on 1 followed by metalation to form a dissymmetrical CoIII complex with a mixed diamidato-N, thiolato-S, sulfinato-S donor set in 2 that is related to the nitrile hydratase active site. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z500814_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.