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Novel pH-Reporter MRI Contrast Agents
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2002
Year
EngineeringImaging AgentMagnetic ResonanceAmide ProtonsBiomedical EngineeringChemistryMagnetic Resonance ImagingChemical ImageMolecular ImagingNuclear MedicineBiophysicsRadiologyMedical ImagingPhotochemistryContrast AgentPharmacologyMagnetic Resonance SpectroscopySolvent Water ResonanceBiomedical ImagingResonanceMedicineSaturation TransferDrug Analysis
Attractive alternatives to conventional contrast agents for magnetic resonance imaging applications are the paramagnetic chemical exchange saturation transfer (CEST) agents based on saturation transfer (ST) to the solvent water resonance. The ratio of ST effects obtained upon irradiating Ln-coordinated water and amide protons in [Ln(dotamGly)] (dotam=1,4,7,10-tetrakis(carbamoylmethyl)-1,4,7,10-tetrazacyclododecane; see picture) complexes is pH dependent and concentration independent.