Single and Multidose Ocular Kinetics and Stability Analysis of Extemporaneous Formulation of Topical Voriconazole in Humans

Abstract

The present study showed that the achieved mean concentration of VZ in both single dose and multi dose kinetic studies satisfactorily met the MIC(90) for almost all causative fungal organisms. The frequency of instillation may be designed for an "every 2 hr regimen" to maintain a therapeutic concentration for successful therapy.