Delineation of PLA₂ epitopes using short or long overlapping synthetic peptides: interest for specific immunotherapy

Abstract

15mer peptides might not be sensitive enough to fully delineate all potential T-cell epitopes scattered along the allergen. Since they do not bind IgE in vitro or only weakly, and taking into account a T-cell response frequently directed to multiple epitopes, long overlapping peptides may represent ideal tools for immunotherapy.