Role of HGF in epithelial–stromal cell interactions during progression from benign breast disease to ductal carcinoma in situ

Abstract

Coordinated and complementary changes in HGF/MET expression occur in epithelium and stroma during progression of pre-invasive basal-like lesions. These results suggest that targeting stroma-derived HGF signaling in early carcinogenesis may block progression of basal-like precursor lesions.