Variants in <i>PPP3R1</i> and <i>MAPT</i> are associated with more rapid functional decline in Alzheimer's disease: The Cache County Dementia Progression Study

Abstract

We replicate a previous report by Cruchaga et al that specific variations in rs3785883 and rs1868402 are associated with accelerated progression of AD. Further characterization of this association will provide a better understanding of how genetic factors influence the rate of progression of AD and could provide novel insights into preventative and therapeutic strategies.