Concepedia

Detection of 23 Immunogenic Pneumococcal Proteins Using Convalescent-Phase Serum

Gregor Zysk, R. J. M. Bongaerts, Elke ten Thoren, Gesina Bethe, Regine Hakenbeck, Hans‐Peter Heinz

Infection and Immunity · 2000 · 45 citations · 16 references

DOI

Concepts

Abstract

A genomic expression library of Streptococcus pneumoniae was screened with a convalescent-phase serum for immunoreactive proteins. Six known and 17 unknown pneumococcal proteins were detected. Five of the known proteins were surface-located virulence factors, and eight of the unknown proteins were putative membrane proteins.

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