Chemical Communications · 2006 · 44 citations · 23 references
Natural SciencesBiochemistryChemistryCatalysisChemical KineticsEnzyme MechanismAmino Acid ChemistryCatalytic MechanismsCatalytic Reaction KineticsChemical Reaction KineticsEnzyme CatalysisReaction MechanismsAmination ReactionsCatalytic Cycle AnalysisCatalytic Cycle MechanismsCatalytic Reaction MechanismsDesign PrinciplesDesign RationalizationKinetics Of Peptide Bond FormationRing-forming Reactions
Kinetic evidence supports the role of the reaction product in the catalytic cycle of proline-mediated alpha-aminoxylation and alpha-amination reactions, providing both design principles as well as a model for the evolution of efficiency in catalysis.
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