2009 · 43 citations · 0 references
Life SciencesToxicologyInnate ImmunityNanobiotechnologyNanomaterialsAntioxidant DefenseMetal Oxide NanomaterialsNanomedicineNanotoxicologyOxidative Damage To BiomoleculesReactive Oxygen SpeciesCell Integrity PreservationFree Radical ScavengingNanoparticle CytotoxicityNanoparticle-induced CytotoxicityOxidative Stress In EpitheliumOxidative Stress InjurySustainable Feed ResourcesToxicity Of Metal Oxide Nanomaterials
Abstract: Nano-ZnO is a new products which may used to be feed resources. The aim of this study was to exam whether nano-ZnO is able to protect cell integrity from potential damage by free-radical oxidative injury. A 3×3 factorial experiment was used to investigate the interaction between particle diameter (15, 50 and 100 nm)-1 and concentration (0.4, 1.6 and 6.4 µg mL) of the primary culture mice intestinal epithelium cell (IEC) in in vitro. The results indicated that the all the nano-ZnO groups MTT OD value were significantly higher than the perhydrol group (P <0.05) and LDH decreased, but not significant (P>0.05). The MDA content in all the nano-ZnO groups were decreased significant (P<0.01). The SOD and CAT in all nano-ZnO groups were higher than the perhydrol group(P>0.05). The results showed that nano-ZnO released the IEC oxidative injury.