4‐Aryl‐2‐quinolones through a Pseudo‐Domino Heck/Buchwald–Hartwig Reaction in a Molten Tetrabutylammonium Acetate/ Tetrabutylammonium Bromide Mixture

Abstract

Abstract 4‐Aryl‐2‐quinolones can be prepared from readily available o ‐bromocinnamamide and aryl iodides using phosphine‐free palladium( II ) acetate as the precatalyst and a molten tetra( n ‐butyl)ammonium acetate/tetra( n ‐butyl)ammonium bromide mixture as the reaction medium. The reaction proceeds through a pseudo‐domino process involving two mechanistically independent, sequential catalytic cycles: a Heck reaction followed by an intramolecular Buchwald–Hartwig CN bond forming reaction.