Acute Anticonvulsant Effects of Diphenylhydantoin, Phenobarbital, and Carbamazepine: A Combined Electroclinical and Serum Level Study in Amygdaloid Kindled Cats and Baboons

Abstract

This preliminary study utilizing the kindling model of established epilepsy has provided information about the most effective routes of administration for diphenylhydantoin, phenobarbital, and carbamazepine in baboons and cats. The time of peak plasma levels for these drugs has been demonstrated in these animals so that experimental protocols can be designed to deliver the agents at appropriate times prior to the kindling stimulation. In addition, dose-effectiveness data is presented for these species. In 1 baboon, phenobarbital was also seen to suppress photosensitive seizures. The potential usefulness of the kindling model in anticonvulsant research is suggested.