Small · 2011 · 140 citations · 45 references
MedicineOncologyPharmacologyBiomedical ImagingMolecular ImagingNanomaterialsCancer NanomedicineMolecular Imaging In OncologyNanomedicineRaman SpectroscopyTargeted Imaging AgentsTumor ImagingCompetitive InhibitionEpidermal Growth Factor Receptor ImagingMolecular Contrast AgentsMultimodal Contrast AgentsMultimodal Imaging AgentsNanoparticle Imaging AgentsNanoparticle Imaging ProbesRaman Imaging
The affibody functionalization of fluorescent surface-enhanced Raman scattering gold-silica nanoparticles as multimodal contrast agents for molecular imaging specific to epidermal growth factor receptor (EGFR) is reported. This nanoparticle bioconjugate reports EGFR-positive A431 tumors with a signal nearly 35-fold higher than EGFR-negative MDA-435S tumors. The low-level EGFR expression in adjacent healthy tissue is 7-fold lower than in the positive tumors. Validation via competitive inhibition reduces the signal by a factor of six, and independent measurement of EGFR via flow cytometry correlates at R(2) = 0.92.
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Renal clearance of quantum dots
Hak Soo Choi, Wenhao Liu, Preeti Misra et al. · Nature Biotechnology · 2007 · 4.4K citations · Full text
DNA-programmable nanoparticle crystallization
Abigail K. R. Lytton‐Jean, Byeongdu Lee, Steven Weigand et al. · Nature · 2008 · 1.5K citations