A long-term, open-label trial of the safety and efficacy of etanercept (Enbrel) in patients with rheumatoid arthritis not treated with other disease-modifying antirheumatic drugs

A Trial of Etanercept, a Recombinant Tumor Necrosis Factor Receptor:Fc Fusion Protein, in Patients with Rheumatoid Arthritis Receiving Methotrexate

Michael E. Weinblatt, Joel M. Kremer, Arthur D. Bankhurst et al. · New England Journal of Medicine · 1999 · 2.1K citations · Full text

Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial

Lars Klareskog, Désirée van der Heijde, J Jäger et al. · The Lancet · 2004 · 1.8K citations

Rheumatoid Disorder, Rheumatology, Therapeutic Effect +8

A Comparison of Etanercept and Methotrexate in Patients with Early Rheumatoid Arthritis

Joan M. Bathon, Richard W. Martin, Roy Fleischmann et al. · New England Journal of Medicine · 2000 · 1.8K citations · Full text

Tumor necrosis factor-α is required in the protective immune response against mycobacterium tuberculosis in mice

JoAnne L. Flynn, Marsha M. Goldstein, John Chan et al. · Immunity · 1995 · 1.7K citations · Full text

Treatment of Rheumatoid Arthritis with a Recombinant Human Tumor Necrosis Factor Receptor (p75)–Fc Fusion Protein

Larry W. Moreland, Scott W. Baumgartner, Michael Schiff et al. · New England Journal of Medicine · 1997 · 1.6K citations · Full text

Immunology, Immune Regulation, Pathology +19