Inhibition of Bone Morphogenic Protein 4 Restores Endothelial Function in <i>db/db</i> Diabetic Mice

Abstract

Inhibition of BMP4/activin receptor-like kinase 3/reactive oxygen species signaling improved endothelial function in diabetic mice through limiting oxidative stress in endothelium. Inhibiting BMP4 cascade can become another potential therapeutic strategy against diabetic vascular dysfunction.