Depletion of T-tubules and specific subcellular changes in sarcolemmal proteins in tachycardia-induced heart failure

Abstract

Failing canine ventricular myocytes exhibit prominent depletion of T-tubules and changes in the density of a variety of proteins in both surface and T-tubular sarcolemma but with preservation of the protein composition of junctional complexes. This subcellular remodeling contributes to abnormal excitation-contraction coupling in heart failure.