Publication | Closed Access
Studies on Specific Transplantation Resistance to Polyoma-Virus-Induced Tumors. IV. Stability of the Polyoma Cell Antigen<xref ref-type="fn" rid="FN2">2</xref>
41
Citations
0
References
1964
Year
Polyoma TumorTransplantationPolyoma-virus-induced TumorsImmunologyPathologyVirologyTherapeutic VaccineCell TransplantationSpecific Transplantation ResistanceImmunosuppressionPolyoma Cell AntigenGraft RejectionMedicineRadiation OncologyPolyoma-specific Cell AntigenTumor BiologyViral OncologyCancer-associated Virus
The stability of the polyoma-specific cell antigen was studied. Thirteen single-cell clones of a polyoma tumor induced in vivo were equally susceptible to the polyoma-induced transplantation resistance, but were previously shown to vary with regard to other properties, such as spontaneous virus release, karyotype, or sensitivity to infection with polyoma or vaccinia virus. Two polyoma tumors were passaged serially 42 and 19 times, respectively, in virus-infected mice with a minimum super-threshold cell dose without any significant change in antigenicity, which indicated a remarkable stability of the polyoma cell antigen. In contrast to the polyoma tumors a methylcholanthrene-induced MCB sarcoma, exceptional because it was susceptible to polyoma-induced resistance, lost most of its susceptibility on 21 passages in virus-immune mice.