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Photomodulation of the Conformation of Cyclic Peptides with Azobenzene Moieties in the Peptide Backbone
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1999
Year
Cisright HarpoonAzobenzene Building BlockBiochemistryPhotochemistryProtein FoldingMechanistic PhotochemistryPhotochromismAzobenzene MoietiesPeptide EngineeringMolecular SwitchConformational StudyPeptide SynthesisCyclic PeptidesMedicineCis IsomerBiophysicsBiomolecular EngineeringPeptide Backbone
The cisright harpoon over left harpoon trans photoisomerization of the azobenzene building block 4-(4-aminophenylazo)benzoic acid incorporated in a cyclic peptide (see scheme) facilitated a two-state transition of the peptide chain from a rigid constrained conformation in the trans isomer into the largely free conformational space of the cis isomer.