Characterization of Chemical Constituents in<i>Scutellaria baicalensis</i>with Antiandrogenic and Growth-Inhibitory Activities toward Prostate Carcinoma

Abstract

Most of the anticancer activities of S. baicalensis can be recapitulated with four purified constituents that function in part through inhibition of the androgen receptor signaling pathway. We conclude that clinical studies evaluating the efficacy of these agents in the context of chemoprevention or the treatment of prostate cancer are warranted.