Effect of Prostaglandins on Gatecholamine Induced Changes in the Free Fatty Acids of Plasma and in Blood Pressure in the Dog Prostaglandin and related factors 22

Abstract

Abstract Prostaglandins E 1 , E 2 , E 3 and F 1α (PGE 1 etc) were given intravenously to anesthetized dogs during continuous infusion of norepinephrine. PGE 1 , PGE 2 and PGE 3 in doses of 5 micrograms all significantly reduced the arterial concentration of the free fatty acids of plasma (FFA) and the blood pressure, while the same dose of PGF 1α had no significant effect. Continuous intraarterial infusions of PGE 1 during continuous infusion of norepinephrine had a more pronounced effect on FFA and blood pressure than continuous intravenous infusions. Infusion of PGE 1 almost completely blocked the usual increase of FFA caused by epinephrine and also resulted in a blood pressure fall during epinephrine infusion. PGE 1 diminished the plasma glucose response to epinephrine only slightly. Studies on the turnover rate of FFA with labeled albumin bound palmitate showed that PGE 1 completely blocked the norepinephrine induced stimulation of lipid mobilization. Infusion of PGE 1 during continuous infusion of norepinephrine also decreased the elevated plasma glycerol concentration.