Ser49Gly of β-adrenergic receptor is associated with effective β-blocker dose in dilated cardiomyopathy

Abstract

In patients with heart failure, the influence of codon 49 on the outcome and effect of beta-blockers appeared to be more pronounced than that of codon 389. The more common Ser49Ser genotype responded less beneficially to beta-blockade and would motivate genotyping to promote higher doses for the best outcome effect.