Membrane current changes in left ventricular myocytes isolated from guinea pigs after abdominal aortic coarctation

Abstract

After infrarenal aortic coarctation, action potential duration of left ventricular myocytes is prolonged. This prolongation may be attributed to an increase in calcium current density and a shift of its inactivation variable, together with an increased magnitude and prolonged time course of sodium-calcium exchange current. These current changes are potentially arrhythmogenic.