Effect of the human SOD1-G93A gene on the Nrf2/ARE signaling pathway in NSC-34 cells

Abstract

quinone oxidoreductase 1 was significantly decreased in the NSC-34 cells transfected with the human SOD1-G93A gene. The present study indicated that human SOD1-G93A damaged the Nrf2/ARE signaling pathway in the ALS cell model and reduced the ability of cells to protect against oxidative injury.