Functional Involvement of PHOSPHO1 in Matrix Vesicle–Mediated Skeletal Mineralization

Abstract

The results show that PHOSPHO1 localization is restricted to mineralizing regions of bone and growth plate and that the enzyme present within MVs is in an active state, inhibition of which decreases the capacity of MVs to mineralize. These data further support our hypothesis that PHOSPHO1 plays a role in the initiation of matrix mineralization.