The Journal of General Physiology · 2013 · 123 citations · 54 references
Life SciencesBiochemistryCell BiologyCell SignalingCellular BiochemistrySignal TransductionCell Signaling NetworksCyclic Nucleotide SignalingIntracellular ReceptorsAdenylate Cyclase RegulationAdenylate Cyclase SignalingAdenylyl Cyclase RegulationAdenylyl Cyclase SignalingCamp SignalingCyclic Adenosine Monophosphate SignalingCyclic Nucleotide PhosphodiesterasesSignal Transduction By Cyclic Nucleotides
### Introduction The concept that cAMP has restricted access to different pools of intracellular effectors was articulated more than 30 years ago. Observations made by [Corbin et al. (1977)][1] demonstrated that the two isoenzymes of the major intracellular cAMP target, PKA I and II, are located in
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