Impaired <scp>l</scp> -Arginine Transport and Endothelial Function in Hypertensive and Genetically Predisposed Normotensive Subjects

Abstract

Similar to their hypertensive counterparts, normotensive individuals at high risk for the development of hypertension are characterized by impaired L-arginine transport, which may represent the link between a defective L-arginine/NO pathway and the onset of essential hypertension. The observed transport defect is not due to apparent alterations in CAT-1 expression or elevated endogenous ADMA.