Inhibition of chemically induced neoplasia by immunization with antigenic carcinogen-protein conjugate.

Abstract

Summary Over 50% tumor inhibition was achieved by immunizing Sprague-Dawley female rats with small amounts of a carcinogen-protein conjugate prior to a single intragastric feeding of 2-anthrylamine, on the basis of numbers of animals developing persistent, palpable tumors. In addition, immunized rats developed fewer tumors, and induction was delayed.