Adipokines as predictors of recovery from upper extremity soft tissue disorders

Abstract

OBJECTIVES: To study the associations of adipokines with recovery from upper extremity soft tissue disorders (UESTDs) and to explore whether overweight or obesity modify these associations. METHODS: In this follow-up study, patients seeking medical advice due to incipient upper extremity symptoms with symptom duration <1 month were included (n = 163). The outcome of the study was full or substantial recovery from UESTDs, assessed at 2, 8 and 12 weeks of follow-up. We studied the associations of four adipokines (leptin, adiponectin, resistin and visfatin) with recovery using the generalized estimating equation. RESULTS: Of the study population, 27.5% reported full or substantial recovery at the 8-week follow-up and 32% at 12 weeks. Higher levels of resistin [odds ratio (OR) = 1.58, 95% CI 1.18, 2.11 for 1 s.d. increase] and visfatin (OR = 1.29, 95% CI 0.94, 1.78 for 1 s.d. increase) at baseline predicted a higher recovery rate at the 8-week follow-up. Moreover, higher levels of leptin predicted a lower rate of recovery (OR = 0.73, 95% CI 0.51, 1.02 for 1 s.d. increase). Adipokines did not predict recovery at 12 weeks. In subgroup analyses, high levels of resistin and visfatin at baseline predicted a higher recovery rate during follow-up in non-overweight patients. CONCLUSION: The adipokines resistin and visfatin predicted recovery from UESTDs and the associations may be related to stimulation of anti-inflammatory response mechanisms. A higher level of leptin may prevent recovery from UESTDs.