Therapeutic action of 5‐<scp>HT</scp>₃ receptor antagonists targeting peritoneal macrophages in post‐operative ileus

Abstract

5-HT3 receptor antagonists were anti-inflammatory, mainly targeting peritoneal macrophages expressing these receptors. They also restored the delayed gastrointestinal transit by IM. 5-HT3 receptor antagonists should be therapeutically useful agents against POI.