Copper‐Catalyzed Cascade Cyclization for the Synthesis of Trifluoromethyl‐Substituted Spiro‐2<i>H</i>‐azirines from 1,6‐Enynes

Abstract

Abstract A method for the synthesis of trifluoromethyl CF 3 ‐substituted spirocyclic compounds containing with a unique quaternary carbon center from readily available starting materials has been developed. The reaction provides a facile access to 2 H ‐azirines via cascade cyclization. These compounds constitute a new class of functionalized synthetic intermediates, which can be used for the synthesis of various nitrogen‐containing heterocycles and biologically active CF 3 ‐containing compounds. magnified image