Effects of ethanol and caffeine on behavior in C57BL/6 mice in the plus-maze discriminative avoidance task.

Abstract

Although caffeine and ethanol interact to modulate behavior in the PMDAT, caffeine does not reverse ethanol-induced learning deficits. Ethanol-induced anxiolysis may contribute to alcohol consumption, while ethanol's blockade of caffeine-induced anxiogenesis may contribute to co-use.