Hypotonic Duodenography with Glucagon

Abstract

In a double blind crossover study, the effects of 2 mg glucagon and 1 mg atropine sulfate on duodenal tonicity and motility were compared to placebo in 6 asymptomatic men. In a similar study, 2 mg glucagon and 30 mg propantheline bromide were compared to placebo. In 10 to 30 minutes after intramuscular administration of the drug there was a significant decrease in duodenal motility and tonicity with glucagon. Both tonicity and motility were near normal at 60 minutes. Responses to atropine sulfate and propantheline bromide were sometimes evident at 10, 30, and 60 minutes, but were variable and not consistently greater than with placebo. With atropine sulfate and propantheline bromide, intensity of reported side effects was greater than with placebo or glucagon.