Gadolinium‐Conjugated Dendrimer Nanoclusters as a Tumor‐Targeted <i>T</i><sub>1</sub> Magnetic Resonance Imaging Contrast Agent

Zhiliang Cheng, Daniel L.J. Thorek, Andrew Tsourkas

Angewandte Chemie International Edition · 2009 · 181 citations · 22 references

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Concepts

Abstract

Light heavyweight champion: Chemically cross-linked dendrimer nanoclusters (DNCs) have been developed as a platform for preparing targeted magnetic resonance contrast agents. The extremely high gadolinium payload causes the DNCs to show a significant improvement in tumor contrast compared with pre-contrast images (see picture).

References

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