QSAR & Combinatorial Science · 2006 · 121 citations · 37 references
Natural SciencesChemistryCatalysisOrganic ChemistryReaction EngineeringAddition ReactionsCross-coupling ReactionsDiversity-oriented SynthesisHeterocycle SynthesisHeterocyclic ChemistryOrganic SynthesisHeterocycle FunctionalizationHeterocyclic ReactivityMedicinal HeterocyclesMulticomponent Heterocycle SynthesisMulticomponent Reaction ChemistryReactivity
Abstract The aim of this mini‐review is to present an overview of the high synthetic potential of Multicomponent Reactions (MCRs) involving the specific reactivity of easily accessible 1,3‐dicarbonyl derivatives. The present contribution only focuses on sequences in which the first step consists of a Michael addition. Recent developments of these new useful methodologies valuable for the selective construction of highly functionalized heterocycles of high synthetic value are surveyed.
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The Atom Economy—A Search for Synthetic Efficiency
100 years of the biginelli dihydropyrimidine synthesis
C. Oliver Kappe · Tetrahedron · 1993 · 1.2K citations