Direct Arylation of Pyrrole Derivatives in Ionic Liquids

Abstract

Abstract An efficient methodology for the direct arylation of pyrrole derivatives has been developed. The reaction proceeds smoothly with a wide range of structurally diverse aryliodides. Derivatives bearing an N , N ‐dimethylamino group at the 1‐position and an aryl substituent at the 2‐position were prepared for the first time. This protocol is more environmentally friendly than those previously reported because it is free of transition metals and utilizes ionic liquids rather than volatile organic solvents.