Subtype-Specific Regulation of P2X3 and P2X2/3 Receptors by Phosphoinositides in Peripheral Nociceptors

Abstract

Our findings indicate a functional regulation of homomeric P2X3 and heteromeric P2X2/3 ATP receptors by phosphoinositides in the plasma membrane of DRG nociceptors, based on subtype-specific mechanisms of direct and indirect lipid sensing.