Highly Enantioselective Direct Michael Addition of Nitroalkanes to Nitroolefins Catalyzed by La(OTf)₃/<i>N</i>,<i>N</i>′‐Dioxide Complexes

Abstract

It all adds up: A chiral La(OTf)3/N,N′-dioxide complex has been developed for the asymmetric direct Michael addition of nitroalkanes to nitroalkenes. This reaction afford 1,3-dinitro compounds with two stereocenters in good yields with high diastereo- and enantioselectivity (up to d.r. 93:3, 97 % ee; see scheme, Tf=trifluoromethanesulfonyl) under mild conditions. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z802285_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.