Peptide Assembly Integration of Fibroblast‐Targeting and Cell‐Penetration Features for Enhanced Antitumor Drug Delivery

Abstract

An integrated cell-penetrating peptide-­assembly-based nanomaterial is engineered as a dual-mode strategy for ­enhancing nanotherapeutic tumor targeting and penetration through recognition and depletion of cancer-associated fibroblasts. The dual-mode strategy is composed of cancer-associated fibroblast-specific antibody targeting for overcoming tissue barrier and cell-penetration peptide-mediated enhanced cellular uptake. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.