Specificity and Mechanism of <i>Acinetobacter baumanii</i> Nicotinamidase: Implications for Activation of the Front‐Line Tuberculosis Drug Pyrazinamide

Abstract

TB or not TB active: The high-resolution crystal structures (see picture) of the zinc-containing metalloenzyme nicotinamidase in complex with nicotinic acid and pyrazinoic acid reveal new aspects of enzyme mechanism that help to explain the activation of a front-line anti-tuberculosis (TB) drug. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.