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Theoretical and synthetic approach to novel spiroheterocycles derived from isatin derivatives and <scp>L</scp>‐proline via 1,3‐dipolar cycloaddition
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Citations
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References
2003
Year
Bioorganic ChemistryEngineeringSynthetic ApproachOrganic ChemistryPeptide ScienceChemistryNovel SpiroheterocyclesHeterocycle ChemistryL ‐ProlineStereoselective SynthesisBiochemistryDiversity-oriented SynthesisIsatin DerivativesPharmacologyEnantioselective SynthesisBiomolecular EngineeringHeterocyclicNatural SciencesTheoretical StudiesSynthetic Chemistry
Abstract A cyclic secondary α‐amino acid, viz. L ‐proline, reacts with isatin derivatives via decarboxylative azomethine ylide formation and subsequent cycloaddition with various dipolarophiles to give cycloadducts in moderate to good yield. Theoretical studies have been performed to study the stereochemistry of the products formed. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:36–41, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10063
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