Notched T Waves on Holter Recordings Enhance Detection of Patients With LQT2 ( <i>HERG</i> ) Mutations

Abstract

This study provides novel evidence that Holter recording analysis is superior to the 12-lead ECG in detecting G1 and G2 T-wave notches. These repolarization abnormalities are more indicative of LQT2 versus LQT1, with G2 notches being most specific and often reflecting HERG core domain missense mutations.