Brain Derived Neurotrophic Factor (BDNF) Contributes to the Pain Hypersensitivity Following Surgical Incision in the Rats

Abstract

The present study showed that incision induced the segmental upregulation of BDNF in the DRG and spinal cord through somatic afferent nerve transmission, and the upregulated BDNF contributed to the pain hypersensitivity induced by surgical incision.