Adiponectin may mediate the association between omentin, circulating lipids and insulin sensitivity: results from the KORA F4 study

Abstract

The data from this large population-based cohort show that circulating omentin levels are associated with insulin sensitivity. Our observations further suggest that omentin acts via upregulation of adiponectin, which in turn affects lipid metabolism and thereby also indirectly enhances insulin sensitivity, but mechanistic studies are required to corroborate this hypothesis.