Angiotensin II-mediated GFR decline in subtotal nephrectomy is due to acid retention associated with reduced GFR

Abstract

AII-mediated GFR decline in 2/3 Nx was induced by H(+) retention and its amelioration with dietary HCO3 conserved GFR better than AII receptor antagonism in this CKD model. H(+) retention might induce AII-mediated GFR decline in patients with reduced GFR, even without metabolic acidosis.