Concepedia

Publication | Open Access

TLR4 enhances histamine-mediated pruritus by potentiating TRPV1 activity

DOIFull Paper Access

60

Citations

22

References

2014

Year

Hyunjung Min, Hyunkyoung Lee, Hyoungsub Lim, Yong Ho Jang, Sung Jun Chung, C. Justin Lee, Sung Joong Lee
Molecular Brain

Abstract

Our data show that TLR4 on sensory neurons enhances histamine-induced itch signal transduction by potentiating TRPV1 activity. The results suggest that TLR4 could be a novel target for the treatment of enhanced itch sensation.

References

YearCitations

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